Drug interactions
Indinavir + Insulin glargine
Severity: Moderate
Indinavir and Insulin glargine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir can cause insulin resistance and hyperglycemia, which may worsen glycemic control in insulin-treated patients. Higher insulin doses are sometimes needed.
What this interaction means in plain words
Indinavir and Insulin glargine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Protease inhibitors impair insulin-mediated glucose uptake, in part by inhibiting GLUT4, causing insulin resistance.
What to do
Monitor blood glucose frequently after starting indinavir and titrate insulin glargine upward as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glargine
Frequently asked questions
Can I take Indinavir with Insulin glargine?
MediHelp rates the interaction as moderate. Indinavir and Insulin glargine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indinavir can cause insulin resistance and hyperglycemia, which may worsen glycemic control in insulin-treated patients. Higher insulin doses are sometimes needed.
How serious is the interaction between Indinavir and Insulin glargine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently after starting indinavir and titrate insulin glargine upward as needed.
What other medicines interact with Insulin glargine?
MediHelp also lists interactions of Insulin glargine with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin glargine page.
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