Drug interactions
Indinavir + Itraconazole
Severity: Moderate
Indinavir and Itraconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole raises indinavir exposure and indinavir may raise itraconazole levels, since both are CYP3A4 substrates and inhibitors. Higher indinavir levels may increase the risk of nephrolithiasis and hyperbilirubinemia.
What this interaction means in plain words
Indinavir and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated metabolism of indinavir by itraconazole, with reciprocal inhibition.
What to do
Reduce unboosted indinavir to 600 mg every 8 hours with itraconazole. Maintain hydration and monitor for renal and hepatic adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Indinavir with Itraconazole?
MediHelp rates the interaction as moderate. Indinavir and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole raises indinavir exposure and indinavir may raise itraconazole levels, since both are CYP3A4 substrates and inhibitors. Higher indinavir levels may increase the risk of nephrolithiasis and hyperbilirubinemia.
How serious is the interaction between Indinavir and Itraconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce unboosted indinavir to 600 mg every 8 hours with itraconazole. Maintain hydration and monitor for renal and hepatic adverse effects.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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