Drug interactions
Indinavir + Liraglutide
Severity: Moderate
Indinavir and Liraglutide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir, an HIV protease inhibitor, is associated with insulin resistance and hyperglycemia that may reduce the effect of liraglutide. The size of the effect differs between patients.
What this interaction means in plain words
Indinavir and Liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Protease inhibitors impair insulin sensitivity and glucose uptake, pharmacodynamically opposing liraglutide.
What to do
Monitor blood glucose and HbA1c after starting or changing antiretroviral therapy. Titrate antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Liraglutide
Frequently asked questions
Can I take Indinavir with Liraglutide?
MediHelp rates the interaction as moderate. Indinavir and Liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indinavir, an HIV protease inhibitor, is associated with insulin resistance and hyperglycemia that may reduce the effect of liraglutide. The size of the effect differs between patients.
How serious is the interaction between Indinavir and Liraglutide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting or changing antiretroviral therapy. Titrate antidiabetic therapy as needed.
What other medicines interact with Liraglutide?
MediHelp also lists interactions of Liraglutide with, for example, Insulin degludec-liraglutide, Insulin glargine-lixisenatide, Alogliptin-metformin. The full list is on the Liraglutide page.
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