Drug interactions
Indinavir + Loperamide
Severity: Moderate
Indinavir and Loperamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir inhibits CYP3A4 and P-glycoprotein, which can increase loperamide concentrations. Higher exposure raises the risk of opioid-like central effects and QT prolongation.
What this interaction means in plain words
Indinavir and Loperamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4 metabolism and P-gp efflux of loperamide.
What to do
Avoid exceeding labeled loperamide doses and monitor for sedation, constipation and palpitations; consider ECG in patients with additional QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Indinavir and Loperamide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Loperamide
Frequently asked questions
Can I take Indinavir with Loperamide?
MediHelp rates the interaction as moderate. Indinavir and Loperamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indinavir inhibits CYP3A4 and P-glycoprotein, which can increase loperamide concentrations. Higher exposure raises the risk of opioid-like central effects and QT prolongation.
How serious is the interaction between Indinavir and Loperamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid exceeding labeled loperamide doses and monitor for sedation, constipation and palpitations; consider ECG in patients with additional QT risk factors.
What other medicines interact with Loperamide?
MediHelp also lists interactions of Loperamide with, for example, Amiodarone, Amisulpride, Anagrelide. The full list is on the Loperamide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
