Drug interactions
Indinavir + Norethisterone
Severity: Moderate
Indinavir and Norethisterone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir inhibits CYP3A4 and has been shown to increase norethisterone exposure modestly. This may increase progestogen-related adverse effects, but contraceptive efficacy is not expected to be reduced.
What this interaction means in plain words
Indinavir and Norethisterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Indinavir inhibits CYP3A4-mediated metabolism of norethisterone.
What to do
Monitor for progestogenic adverse effects and consider dose reduction if they are troublesome. Counsel the patient on tolerability and when to seek review.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Norethisterone
- Acitretin + Norethisterone Contraindicated
- Amobarbital + Norethisterone Major
- Apalutamide + Norethisterone Major
- Belzutifan + Norethisterone Major
- Bosentan + Norethisterone Major
- Brigatinib + Norethisterone Major
Frequently asked questions
Can I take Indinavir with Norethisterone?
MediHelp rates the interaction as moderate. Indinavir and Norethisterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indinavir inhibits CYP3A4 and has been shown to increase norethisterone exposure modestly. This may increase progestogen-related adverse effects, but contraceptive efficacy is not expected to be reduced.
How serious is the interaction between Indinavir and Norethisterone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for progestogenic adverse effects and consider dose reduction if they are troublesome. Counsel the patient on tolerability and when to seek review.
What other medicines interact with Norethisterone?
MediHelp also lists interactions of Norethisterone with, for example, Acitretin, Amobarbital, Apalutamide. The full list is on the Norethisterone page.
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