Drug interactions
Indinavir + Paliperidone
Severity: Moderate
Indinavir and Paliperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir inhibits P-glycoprotein, which helps limit paliperidone absorption and promote its elimination, so paliperidone levels may rise. This could increase sedation, extrapyramidal effects and QT prolongation.
What this interaction means in plain words
Indinavir and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of P-glycoprotein efflux increases paliperidone bioavailability and reduces its clearance.
What to do
Monitor for adverse effects of paliperidone and consider a dose reduction if they appear. Use ECG monitoring if other QT risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Frequently asked questions
Can I take Indinavir with Paliperidone?
MediHelp rates the interaction as moderate. Indinavir and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indinavir inhibits P-glycoprotein, which helps limit paliperidone absorption and promote its elimination, so paliperidone levels may rise. This could increase sedation, extrapyramidal effects and QT prolongation.
How serious is the interaction between Indinavir and Paliperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for adverse effects of paliperidone and consider a dose reduction if they appear. Use ECG monitoring if other QT risk factors are present.
What other medicines interact with Paliperidone?
MediHelp also lists interactions of Paliperidone with, for example, Ibutilide, Pimozide, Vandetanib. The full list is on the Paliperidone page.
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