Drug interactions
Indinavir + Pravastatin
Severity: Moderate
Indinavir and Pravastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir may increase pravastatin exposure, raising the risk of myopathy. Pravastatin is generally the preferred statin with protease inhibitors because it is not significantly CYP3A4 metabolised.
What this interaction means in plain words
Indinavir and Pravastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Indinavir may inhibit OATP1B1-mediated hepatic uptake of pravastatin.
What to do
Start pravastatin at a low dose and titrate to lipid response while monitoring for muscle symptoms; check CK if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Indinavir and Pravastatin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Pravastatin
Frequently asked questions
Can I take Indinavir with Pravastatin?
MediHelp rates the interaction as moderate. Indinavir and Pravastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indinavir may increase pravastatin exposure, raising the risk of myopathy. Pravastatin is generally the preferred statin with protease inhibitors because it is not significantly CYP3A4 metabolised.
How serious is the interaction between Indinavir and Pravastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start pravastatin at a low dose and titrate to lipid response while monitoring for muscle symptoms; check CK if symptoms occur.
What other medicines interact with Pravastatin?
MediHelp also lists interactions of Pravastatin with, for example, Cyclosporine, Cyclosporin, Gemfibrozil. The full list is on the Pravastatin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
