Drug interactions
Indinavir + Rimegepant
Severity: Major
Indinavir and Rimegepant: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir inhibits CYP3A4 strongly and may markedly increase rimegepant exposure. This raises the risk of dose-related adverse effects, and the labeling advises against the combination.
What this interaction means in plain words
Indinavir and Rimegepant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Inhibition of CYP3A4 metabolism of rimegepant.
What to do
Avoid concomitant use and choose an alternative migraine treatment during indinavir therapy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Rimegepant
Frequently asked questions
Can I take Indinavir with Rimegepant?
MediHelp rates the interaction as major. Indinavir and Rimegepant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Indinavir inhibits CYP3A4 strongly and may markedly increase rimegepant exposure. This raises the risk of dose-related adverse effects, and the labeling advises against the combination.
How serious is the interaction between Indinavir and Rimegepant?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use and choose an alternative migraine treatment during indinavir therapy.
What other medicines interact with Rimegepant?
MediHelp also lists interactions of Rimegepant with, for example, Amobarbital, Atazanavir, Butabarbital. The full list is on the Rimegepant page.
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