Drug interactions
Indinavir + Rosuvastatin
Severity: Moderate
Indinavir and Rosuvastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir may increase rosuvastatin exposure and the risk of myopathy. The effect is smaller than with other boosted protease inhibitors.
What this interaction means in plain words
Indinavir and Rosuvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of OATP1B1 hepatic uptake raises rosuvastatin levels; rosuvastatin undergoes little CYP3A4 metabolism.
What to do
Use the lowest effective rosuvastatin dose and monitor for muscle symptoms. Check CK if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rosuvastatin
Frequently asked questions
Can I take Indinavir with Rosuvastatin?
MediHelp rates the interaction as moderate. Indinavir and Rosuvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indinavir may increase rosuvastatin exposure and the risk of myopathy. The effect is smaller than with other boosted protease inhibitors.
How serious is the interaction between Indinavir and Rosuvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective rosuvastatin dose and monitor for muscle symptoms. Check CK if symptoms occur.
What other medicines interact with Rosuvastatin?
MediHelp also lists interactions of Rosuvastatin with, for example, Atazanavir, Cyclosporine, Cyclosporin. The full list is on the Rosuvastatin page.
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