Drug interactions
Indinavir + Voriconazole
Severity: Moderate
Indinavir and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole inhibits CYP3A4 and can increase indinavir exposure, increasing risks such as nephrolithiasis and hyperbilirubinemia. Indinavir has not been shown to alter voriconazole substantially.
What this interaction means in plain words
Indinavir and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Voriconazole inhibits CYP3A4-mediated metabolism of indinavir.
What to do
Consider reducing the indinavir dose as labeled and ensure good hydration. Monitor for renal stones, bilirubin elevation and indinavir toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Indinavir with Voriconazole?
MediHelp rates the interaction as moderate. Indinavir and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole inhibits CYP3A4 and can increase indinavir exposure, increasing risks such as nephrolithiasis and hyperbilirubinemia. Indinavir has not been shown to alter voriconazole substantially.
How serious is the interaction between Indinavir and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the indinavir dose as labeled and ensure good hydration. Monitor for renal stones, bilirubin elevation and indinavir toxicity.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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