Drug interactions
Indomethacin + Lisinopril
Severity: Major
Indomethacin and Lisinopril: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indomethacin can reduce the antihypertensive effect of lisinopril and may worsen renal function, especially in elderly, dehydrated or renally impaired patients. Hyperkalemia can also occur.
What this interaction means in plain words
Indomethacin and Lisinopril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Indomethacin belongs to Musculoskeletal; Lisinopril belongs to Cardiovascular.
Why it happens
Inhibition of renal prostaglandin synthesis by the NSAID counteracts ACE inhibitor vasodilation and reduces glomerular filtration.
What to do
Use an alternative analgesic where possible. If coadministered, maintain hydration and monitor blood pressure, serum creatinine and potassium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Other interactions of Lisinopril
- Aliskiren + Lisinopril Contraindicated
- Lisinopril + Protein a column Contraindicated
- Lisinopril + Sacubitril / valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Lisinopril Major
- Amiloride + Lisinopril Major
Frequently asked questions
Can I take Indomethacin with Lisinopril?
MediHelp rates the interaction as major. Indomethacin and Lisinopril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Indomethacin can reduce the antihypertensive effect of lisinopril and may worsen renal function, especially in elderly, dehydrated or renally impaired patients. Hyperkalemia can also occur.
How serious is the interaction between Indomethacin and Lisinopril?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative analgesic where possible. If coadministered, maintain hydration and monitor blood pressure, serum creatinine and potassium.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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