Drug interactions
Indomethacin + Mavacamten
Severity: Moderate
Indomethacin and Mavacamten: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mavacamten is metabolized substantially by CYP2C19, and indomethacin was suggested to weakly inhibit it, which could increase mavacamten exposure. Excess exposure can reduce ejection fraction and cause heart failure.
What this interaction means in plain words
Indomethacin and Mavacamten can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indomethacin belongs to Musculoskeletal; Mavacamten belongs to Cardiovascular.
Why it happens
Possible weak CYP2C19 inhibition by indomethacin reducing mavacamten clearance.
What to do
Monitor LVEF and clinical status per mavacamten labeling when starting indomethacin, and reduce the mavacamten dose if exposure-related effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Other interactions of Mavacamten
- Apalutamide + Mavacamten Contraindicated
- Carbamazepine + Mavacamten Contraindicated
- Clarithromycin + Mavacamten Contraindicated
- Dexlansoprazole + Mavacamten Contraindicated
- Efavirenz + Mavacamten Contraindicated
- Enzalutamide + Mavacamten Contraindicated
Frequently asked questions
Can I take Indomethacin with Mavacamten?
MediHelp rates the interaction as moderate. Indomethacin and Mavacamten can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mavacamten is metabolized substantially by CYP2C19, and indomethacin was suggested to weakly inhibit it, which could increase mavacamten exposure. Excess exposure can reduce ejection fraction and cause heart failure.
How serious is the interaction between Indomethacin and Mavacamten?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor LVEF and clinical status per mavacamten labeling when starting indomethacin, and reduce the mavacamten dose if exposure-related effects appear.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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