Drug interactions
Indomethacin + Ofloxacin
Severity: Moderate
Indomethacin and Ofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may increase the CNS stimulating and seizure-provoking potential of fluoroquinolones. The risk is greatest in patients with epilepsy, prior seizures, renal impairment or other seizure risk factors.
What this interaction means in plain words
Indomethacin and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indomethacin belongs to Musculoskeletal; Ofloxacin belongs to Anti Bacterial.
Why it happens
Fluoroquinolone inhibition of GABA-A receptor binding, which NSAIDs may enhance.
What to do
Avoid the combination in patients with seizure history or other predisposing factors; otherwise use the lowest effective doses and stop the fluoroquinolone if neurological symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Frequently asked questions
Can I take Indomethacin with Ofloxacin?
MediHelp rates the interaction as moderate. Indomethacin and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may increase the CNS stimulating and seizure-provoking potential of fluoroquinolones. The risk is greatest in patients with epilepsy, prior seizures, renal impairment or other seizure risk factors.
How serious is the interaction between Indomethacin and Ofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in patients with seizure history or other predisposing factors; otherwise use the lowest effective doses and stop the fluoroquinolone if neurological symptoms occur.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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