Drug interactions
Indomethacin + Streptomycin
Severity: Moderate
Indomethacin and Streptomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
In preterm infants, indomethacin given for patent ductus arteriosus closure can reduce renal function and raise aminoglycoside concentrations. This increases the risk of nephrotoxicity and ototoxicity.
What this interaction means in plain words
Indomethacin and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indomethacin belongs to Musculoskeletal; Streptomycin belongs to Anti Bacterial.
Why it happens
Indomethacin reduces renal prostaglandin-dependent perfusion and glomerular filtration, lowering aminoglycoside clearance.
What to do
In neonates, monitor serum aminoglycoside levels and renal function and adjust dosing interval accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Other interactions of Streptomycin
Frequently asked questions
Can I take Indomethacin with Streptomycin?
MediHelp rates the interaction as moderate. Indomethacin and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. In preterm infants, indomethacin given for patent ductus arteriosus closure can reduce renal function and raise aminoglycoside concentrations. This increases the risk of nephrotoxicity and ototoxicity.
How serious is the interaction between Indomethacin and Streptomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: In neonates, monitor serum aminoglycoside levels and renal function and adjust dosing interval accordingly.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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