Drug interactions
Indomethacin + Tenecteplase
Severity: Major
Indomethacin and Tenecteplase: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tenecteplase dissolves clots and indomethacin impairs platelet function and can injure the gastric lining. Used together, the risk of serious bleeding is increased.
What this interaction means in plain words
Indomethacin and Tenecteplase can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Indomethacin belongs to Musculoskeletal; Tenecteplase belongs to Cardiovascular.
Why it happens
Additive hemostatic impairment from fibrinolysis by tenecteplase and platelet COX-1 inhibition by indomethacin.
What to do
Avoid NSAIDs around thrombolytic therapy unless essential, and monitor closely for bleeding including gastrointestinal and intracranial signs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Other interactions of Tenecteplase
- Alteplase + Tenecteplase Contraindicated
- Acetylsalicylic acid + Tenecteplase Major
- Apixaban + Tenecteplase Major
- Argatroban + Tenecteplase Major
- Dabigatran etexilate + Tenecteplase Major
- Dalteparin + Tenecteplase Major
Frequently asked questions
Can I take Indomethacin with Tenecteplase?
MediHelp rates the interaction as major. Indomethacin and Tenecteplase can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tenecteplase dissolves clots and indomethacin impairs platelet function and can injure the gastric lining. Used together, the risk of serious bleeding is increased.
How serious is the interaction between Indomethacin and Tenecteplase?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid NSAIDs around thrombolytic therapy unless essential, and monitor closely for bleeding including gastrointestinal and intracranial signs.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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