Drug interactions
Indomethacin + Terazosin
Severity: Moderate
Indomethacin and Terazosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indomethacin is among the NSAIDs most likely to blunt antihypertensive therapy and may reduce the effect of terazosin. Blood pressure control may deteriorate with regular use.
What this interaction means in plain words
Indomethacin and Terazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indomethacin belongs to Musculoskeletal; Terazosin belongs to Genitourinary.
Why it happens
Inhibition of prostaglandin synthesis causes sodium and fluid retention and reduces vasodilatory prostaglandin effects.
What to do
Monitor blood pressure when indomethacin is used regularly, and consider an alternative analgesic if control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Terazosin
- Alfuzosin + Terazosin Major
- Amifostine + Terazosin Major
- Avanafil + Terazosin Major
- Doxazosin + Terazosin Major
- Dutasteride-tamsulosin + Terazosin Major
- Lofexidine + Terazosin Major
Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Frequently asked questions
Can I take Indomethacin with Terazosin?
MediHelp rates the interaction as moderate. Indomethacin and Terazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indomethacin is among the NSAIDs most likely to blunt antihypertensive therapy and may reduce the effect of terazosin. Blood pressure control may deteriorate with regular use.
How serious is the interaction between Indomethacin and Terazosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when indomethacin is used regularly, and consider an alternative analgesic if control is lost.
What other medicines interact with Terazosin?
MediHelp also lists interactions of Terazosin with, for example, Alfuzosin, Amifostine, Avanafil. The full list is on the Terazosin page.
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