Drug interactions
Indomethacin + Tiludronate
Severity: Minor
Indomethacin and Tiludronate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral indomethacin was found to increase the bioavailability of oral tiludronate. Because bisphosphonates also irritate the upper GI tract, the combination may add to GI toxicity.
What this interaction means in plain words
Indomethacin and Tiludronate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Indomethacin belongs to Musculoskeletal; Tiludronate belongs to Musculoskeletal.
Why it happens
Increased absorption of tiludronate when co-administered with indomethacin; the exact mechanism is not fully defined.
What to do
Monitor for upper GI symptoms; a dose change is generally unnecessary, but administer tiludronate as labeled, with water and separate from other medicines.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Indomethacin and Tiludronate, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Other interactions of Tiludronate
- Acetylsalicylic acid + Tiludronate Moderate
- Aluminum hydroxide + Tiludronate Moderate
- Calcium acetate + Tiludronate Moderate
- Calcium carbonate + Tiludronate Moderate
- Calcium chloride + Tiludronate Moderate
- Calcium citrate + Tiludronate Moderate
Frequently asked questions
Can I take Indomethacin with Tiludronate?
MediHelp rates the interaction as minor. Indomethacin and Tiludronate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral indomethacin was found to increase the bioavailability of oral tiludronate. Because bisphosphonates also irritate the upper GI tract, the combination may add to GI toxicity.
How serious is the interaction between Indomethacin and Tiludronate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for upper GI symptoms; a dose change is generally unnecessary, but administer tiludronate as labeled, with water and separate from other medicines.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
