Drug interactions
Indomethacin + Valganciclovir
Severity: Minor
Indomethacin and Valganciclovir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valganciclovir is converted to ganciclovir, which is cleared renally by filtration and tubular secretion. NSAIDs may compete for secretion or lower renal function, potentially increasing ganciclovir exposure and hematologic toxicity.
What this interaction means in plain words
Indomethacin and Valganciclovir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Indomethacin belongs to Musculoskeletal; Valganciclovir belongs to Anti Virals.
Why it happens
Possible competition for renal tubular secretion plus NSAID-related reduction in renal perfusion.
What to do
Monitor renal function and blood counts, and adjust valganciclovir dose to creatinine clearance as labeled.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Other interactions of Valganciclovir
Frequently asked questions
Can I take Indomethacin with Valganciclovir?
MediHelp rates the interaction as minor. Indomethacin and Valganciclovir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Valganciclovir is converted to ganciclovir, which is cleared renally by filtration and tubular secretion. NSAIDs may compete for secretion or lower renal function, potentially increasing ganciclovir exposure and hematologic toxicity.
How serious is the interaction between Indomethacin and Valganciclovir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and blood counts, and adjust valganciclovir dose to creatinine clearance as labeled.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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