Drug interactions
Indomethacin + Valsartan
Severity: Moderate
Indomethacin and Valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indomethacin can reduce the blood pressure lowering effect of valsartan. In older, volume-depleted or renally impaired patients the combination can cause acute kidney injury and hyperkalemia.
What this interaction means in plain words
Indomethacin and Valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indomethacin belongs to Musculoskeletal; Valsartan belongs to Cardiovascular.
Why it happens
NSAIDs block vasodilatory prostaglandins and reduce afferent arteriolar flow, while angiotensin receptor blockade dilates the efferent arteriole, lowering glomerular filtration pressure and impairing potassium excretion.
What to do
Monitor blood pressure, serum creatinine and potassium within the first weeks and after dose changes, and ensure adequate hydration. Avoid or limit NSAID use in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Other interactions of Valsartan
- Aliskiren + Valsartan Contraindicated
- Sparsentan + Valsartan Contraindicated
- Aldesleukin + Valsartan Major
- Amifostine + Valsartan Major
- Amiloride + Valsartan Major
- Amlodipine-benazepril + Valsartan Major
Frequently asked questions
Can I take Indomethacin with Valsartan?
MediHelp rates the interaction as moderate. Indomethacin and Valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indomethacin can reduce the blood pressure lowering effect of valsartan. In older, volume-depleted or renally impaired patients the combination can cause acute kidney injury and hyperkalemia.
How serious is the interaction between Indomethacin and Valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium within the first weeks and after dose changes, and ensure adequate hydration. Avoid or limit NSAID use in high-risk patients.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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