Drug interactions
Infigratinib + Magnesium hydroxide
Severity: Moderate
Infigratinib and Magnesium hydroxide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Infigratinib solubility is pH-dependent, and acid-reducing agents may lower its absorption and exposure. Locally acting antacids have a shorter effect on gastric pH, so the interaction is manageable with timing.
What this interaction means in plain words
Infigratinib and Magnesium hydroxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Increased gastric pH from the antacid reduces dissolution and absorption of infigratinib.
What to do
Take infigratinib at least 2 hours before or 2 hours after magnesium hydroxide. Avoid proton pump inhibitors and H2 blockers with it.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Magnesium hydroxide
Frequently asked questions
Can I take Infigratinib with Magnesium hydroxide?
MediHelp rates the interaction as moderate. Infigratinib and Magnesium hydroxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Infigratinib solubility is pH-dependent, and acid-reducing agents may lower its absorption and exposure. Locally acting antacids have a shorter effect on gastric pH, so the interaction is manageable with timing.
How serious is the interaction between Infigratinib and Magnesium hydroxide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take infigratinib at least 2 hours before or 2 hours after magnesium hydroxide. Avoid proton pump inhibitors and H2 blockers with it.
What other medicines interact with Magnesium hydroxide?
MediHelp also lists interactions of Magnesium hydroxide with, for example, Ciprofloxacin, Dolutegravir, Gemifloxacin. The full list is on the Magnesium hydroxide page.
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