Drug interactions
Infigratinib + Omeprazole
Severity: Major
Infigratinib and Omeprazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Infigratinib solubility is pH-dependent, so acid-reducing agents such as omeprazole can lower its absorption and exposure. This may reduce its efficacy in cholangiocarcinoma.
What this interaction means in plain words
Infigratinib and Omeprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Increased gastric pH reduces infigratinib solubility and absorption.
What to do
Avoid PPIs and H2 antagonists. If acid suppression is needed, use a locally acting antacid separated from infigratinib by the interval in the labeling.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Frequently asked questions
Can I take Infigratinib with Omeprazole?
MediHelp rates the interaction as major. Infigratinib and Omeprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Infigratinib solubility is pH-dependent, so acid-reducing agents such as omeprazole can lower its absorption and exposure. This may reduce its efficacy in cholangiocarcinoma.
How serious is the interaction between Infigratinib and Omeprazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid PPIs and H2 antagonists. If acid suppression is needed, use a locally acting antacid separated from infigratinib by the interval in the labeling.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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