Drug interactions
Infigratinib + Ribociclib
Severity: Moderate
Infigratinib and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib is a moderate CYP3A4 inhibitor and may increase infigratinib exposure. This could increase infigratinib toxicities such as hyperphosphatemia, ocular and nail effects.
What this interaction means in plain words
Infigratinib and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Ribociclib inhibits CYP3A4, reducing infigratinib metabolism.
What to do
Monitor for infigratinib adverse effects, including serum phosphate and eye symptoms, and reduce the dose if toxicity develops. Consider an alternative if the combination is not essential.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Infigratinib with Ribociclib?
MediHelp rates the interaction as moderate. Infigratinib and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribociclib is a moderate CYP3A4 inhibitor and may increase infigratinib exposure. This could increase infigratinib toxicities such as hyperphosphatemia, ocular and nail effects.
How serious is the interaction between Infigratinib and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for infigratinib adverse effects, including serum phosphate and eye symptoms, and reduce the dose if toxicity develops. Consider an alternative if the combination is not essential.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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