Drug interactions
Infigratinib + Voriconazole
Severity: Major
Infigratinib and Voriconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole may raise infigratinib concentrations by inhibiting CYP3A4, increasing the risk of toxicities such as hyperphosphatemia and ocular and other adverse effects.
What this interaction means in plain words
Infigratinib and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Voriconazole inhibits CYP3A4-mediated metabolism of infigratinib.
What to do
Avoid strong CYP3A4 inhibitors and select an alternative antifungal. If unavoidable, monitor closely for infigratinib adverse effects, including phosphate and eye symptoms, and reduce the dose if toxicity develops.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Infigratinib with Voriconazole?
MediHelp rates the interaction as major. Infigratinib and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Voriconazole may raise infigratinib concentrations by inhibiting CYP3A4, increasing the risk of toxicities such as hyperphosphatemia and ocular and other adverse effects.
How serious is the interaction between Infigratinib and Voriconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid strong CYP3A4 inhibitors and select an alternative antifungal. If unavoidable, monitor closely for infigratinib adverse effects, including phosphate and eye symptoms, and reduce the dose if toxicity develops.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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