Drug interactions
Infliximab + Influenza virus vaccine quadrivalent intranasal
Severity: Contraindicated
Infliximab and Influenza virus vaccine quadrivalent intranasal: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The intranasal influenza vaccine contains live attenuated virus. In a patient immunosuppressed by infliximab, the vaccine strain could replicate and cause disease, and the immune response may also be reduced.
What this interaction means in plain words
Infliximab and Influenza virus vaccine quadrivalent intranasal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
TNF inhibition impairs immune control of live attenuated virus replication and reduces vaccine response.
What to do
Avoid the live intranasal vaccine during infliximab therapy; use an inactivated injectable influenza vaccine instead.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Infliximab
- Bcg vaccine live + Infliximab Contraindicated
- Infliximab + Measles mumps and rubella vaccine Contraindicated
- Infliximab + Measles mumps and rubella vaccine live Contraindicated
- Infliximab + Measles mumps rubella and varicella vaccine live Contraindicated
- Infliximab + Measles vaccine Contraindicated
- Infliximab + Rubella vaccine Contraindicated
Frequently asked questions
Can I take Infliximab with Influenza virus vaccine quadrivalent intranasal?
MediHelp rates the interaction as contraindicated. Infliximab and Influenza virus vaccine quadrivalent intranasal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. The intranasal influenza vaccine contains live attenuated virus. In a patient immunosuppressed by infliximab, the vaccine strain could replicate and cause disease, and the immune response may also be reduced.
How serious is the interaction between Infliximab and Influenza virus vaccine quadrivalent intranasal?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the live intranasal vaccine during infliximab therapy; use an inactivated injectable influenza vaccine instead.
What other medicines interact with Infliximab?
MediHelp also lists interactions of Infliximab with, for example, Bcg vaccine live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Infliximab page.
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