Drug interactions
Infliximab + Measles vaccine
Severity: Contraindicated
Infliximab and Measles vaccine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Measles vaccine is a live attenuated virus vaccine. In patients taking infliximab, the vaccine virus may replicate uncontrolled and cause disseminated disease, and the vaccine response may be poor.
What this interaction means in plain words
Infliximab and Measles vaccine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
TNF inhibition impairs cell-mediated control of live attenuated virus replication.
What to do
Avoid live vaccines during infliximab therapy and for several months after stopping, generally about 5 half-lives or longer per local guidance. Complete live vaccination at least 4 weeks before starting infliximab when feasible.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Infliximab
- Bcg vaccine live + Infliximab Contraindicated
- Infliximab + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Infliximab + Measles mumps and rubella vaccine Contraindicated
- Infliximab + Measles mumps and rubella vaccine live Contraindicated
- Infliximab + Measles mumps rubella and varicella vaccine live Contraindicated
- Infliximab + Rubella vaccine Contraindicated
Frequently asked questions
Can I take Infliximab with Measles vaccine?
MediHelp rates the interaction as contraindicated. Infliximab and Measles vaccine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Measles vaccine is a live attenuated virus vaccine. In patients taking infliximab, the vaccine virus may replicate uncontrolled and cause disseminated disease, and the vaccine response may be poor.
How serious is the interaction between Infliximab and Measles vaccine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live vaccines during infliximab therapy and for several months after stopping, generally about 5 half-lives or longer per local guidance. Complete live vaccination at least 4 weeks before starting infliximab when feasible.
What other medicines interact with Infliximab?
MediHelp also lists interactions of Infliximab with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine. The full list is on the Infliximab page.
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