Drug interactions
Infliximab + Measles mumps and rubella vaccine live
Severity: Contraindicated
Infliximab and Measles mumps and rubella vaccine live: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MMR contains live attenuated viruses that could cause disseminated vaccine-strain infection in a patient immunosuppressed by infliximab. Vaccine immunogenicity may also be reduced.
What this interaction means in plain words
Infliximab and Measles mumps and rubella vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
TNF inhibition impairs immune control of live attenuated virus replication.
What to do
Do not give during infliximab therapy; wait several months after the last dose per local guidance. Give needed live vaccines at least 4 weeks before starting therapy.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Infliximab
- Bcg vaccine live + Infliximab Contraindicated
- Infliximab + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Infliximab + Measles mumps and rubella vaccine Contraindicated
- Infliximab + Measles mumps rubella and varicella vaccine live Contraindicated
- Infliximab + Measles vaccine Contraindicated
- Infliximab + Rubella vaccine Contraindicated
Frequently asked questions
Can I take Infliximab with Measles mumps and rubella vaccine live?
MediHelp rates the interaction as contraindicated. Infliximab and Measles mumps and rubella vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. MMR contains live attenuated viruses that could cause disseminated vaccine-strain infection in a patient immunosuppressed by infliximab. Vaccine immunogenicity may also be reduced.
How serious is the interaction between Infliximab and Measles mumps and rubella vaccine live?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give during infliximab therapy; wait several months after the last dose per local guidance. Give needed live vaccines at least 4 weeks before starting therapy.
What other medicines interact with Infliximab?
MediHelp also lists interactions of Infliximab with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine. The full list is on the Infliximab page.
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