Drug interactions
Influenza virus vaccine quadrivalent adjuvanted + Liposomal doxorubicin
Severity: Moderate
Influenza virus vaccine quadrivalent adjuvanted and Liposomal doxorubicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cytotoxic chemotherapy can blunt the antibody response to influenza vaccine. The vaccine is inactivated and remains recommended for patients on chemotherapy, so protection may be reduced rather than the vaccine being unsafe.
What this interaction means in plain words
Influenza virus vaccine quadrivalent adjuvanted and Liposomal doxorubicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Myelosuppression and lymphocyte depletion from doxorubicin reduce the vaccine immune response.
What to do
Where possible vaccinate before starting chemotherapy or between cycles away from the nadir. Do not withhold the vaccine, and apply infection precautions.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Liposomal doxorubicin
- Dengue vaccine + Liposomal doxorubicin Contraindicated
- Belatacept + Liposomal doxorubicin Major
- Cyclosporine + Liposomal doxorubicin Major
- Dronedarone + Liposomal doxorubicin Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Liposomal doxorubicin Major
- Fingolimod + Liposomal doxorubicin Major
Frequently asked questions
Can I take Influenza virus vaccine quadrivalent adjuvanted with Liposomal doxorubicin?
MediHelp rates the interaction as moderate. Influenza virus vaccine quadrivalent adjuvanted and Liposomal doxorubicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cytotoxic chemotherapy can blunt the antibody response to influenza vaccine. The vaccine is inactivated and remains recommended for patients on chemotherapy, so protection may be reduced rather than the vaccine being unsafe.
How serious is the interaction between Influenza virus vaccine quadrivalent adjuvanted and Liposomal doxorubicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible vaccinate before starting chemotherapy or between cycles away from the nadir. Do not withhold the vaccine, and apply infection precautions.
What other medicines interact with Liposomal doxorubicin?
MediHelp also lists interactions of Liposomal doxorubicin with, for example, Dengue vaccine, Belatacept, Cyclosporine. The full list is on the Liposomal doxorubicin page.
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