Drug interactions
Influenza virus vaccine quadrivalent adjuvanted + Oxaliplatin
Severity: Moderate
Influenza virus vaccine quadrivalent adjuvanted and Oxaliplatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chemotherapy with oxaliplatin may reduce the antibody response to adjuvanted quadrivalent influenza vaccine, although the adjuvant may partly compensate.
What this interaction means in plain words
Influenza virus vaccine quadrivalent adjuvanted and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cytotoxic immunosuppression reduces vaccine immunogenicity.
What to do
Vaccinate ideally at least 2 weeks before chemotherapy, or between cycles. Do not withhold the seasonal vaccine in patients on treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Frequently asked questions
Can I take Influenza virus vaccine quadrivalent adjuvanted with Oxaliplatin?
MediHelp rates the interaction as moderate. Influenza virus vaccine quadrivalent adjuvanted and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chemotherapy with oxaliplatin may reduce the antibody response to adjuvanted quadrivalent influenza vaccine, although the adjuvant may partly compensate.
How serious is the interaction between Influenza virus vaccine quadrivalent adjuvanted and Oxaliplatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate ideally at least 2 weeks before chemotherapy, or between cycles. Do not withhold the seasonal vaccine in patients on treatment.
What other medicines interact with Oxaliplatin?
MediHelp also lists interactions of Oxaliplatin with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Oxaliplatin page.
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