Drug interactions
Influenza virus vaccine quadrivalent + Mycophenolate mofetil
Severity: Moderate
Influenza virus vaccine quadrivalent and Mycophenolate mofetil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mycophenolate can reduce antibody responses to inactivated influenza vaccine in transplant and other immunosuppressed patients. Vaccination is still recommended because it gives some protection and influenza is dangerous in these patients.
What this interaction means in plain words
Influenza virus vaccine quadrivalent and Mycophenolate mofetil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Suppression of lymphocyte proliferation via IMPDH inhibition lessens vaccine-induced humoral immunity.
What to do
Give the inactivated vaccine annually despite mycophenolate and do not withhold treatment. Consider a high-dose formulation where available and counsel on early antiviral treatment if influenza develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mycophenolate mofetil
- Adenovirus types 4 and 7 live + Mycophenolate mofetil Contraindicated
- Bcg vaccine live + Mycophenolate mofetil Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Mycophenolate mofetil Contraindicated
- Measles mumps and rubella vaccine live + Mycophenolate mofetil Contraindicated
- Measles mumps rubella and varicella vaccine live + Mycophenolate mofetil Contraindicated
- Measles vaccine + Mycophenolate mofetil Contraindicated
Frequently asked questions
Can I take Influenza virus vaccine quadrivalent with Mycophenolate mofetil?
MediHelp rates the interaction as moderate. Influenza virus vaccine quadrivalent and Mycophenolate mofetil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mycophenolate can reduce antibody responses to inactivated influenza vaccine in transplant and other immunosuppressed patients. Vaccination is still recommended because it gives some protection and influenza is dangerous in these patients.
How serious is the interaction between Influenza virus vaccine quadrivalent and Mycophenolate mofetil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the inactivated vaccine annually despite mycophenolate and do not withhold treatment. Consider a high-dose formulation where available and counsel on early antiviral treatment if influenza develops.
What other medicines interact with Mycophenolate mofetil?
MediHelp also lists interactions of Mycophenolate mofetil with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Mycophenolate mofetil page.
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