Drug interactions
Influenza virus vaccine quadrivalent + Sirolimus
Severity: Moderate
Influenza virus vaccine quadrivalent and Sirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sirolimus may lessen the antibody response to inactivated influenza vaccine. The vaccine is still recommended because it can offer partial protection.
What this interaction means in plain words
Influenza virus vaccine quadrivalent and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Sirolimus immunosuppression impairs the antibody response to vaccination.
What to do
Give the inactivated vaccine annually despite sirolimus therapy; consider a high-dose formulation where recommended.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Influenza virus vaccine quadrivalent with Sirolimus?
MediHelp rates the interaction as moderate. Influenza virus vaccine quadrivalent and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sirolimus may lessen the antibody response to inactivated influenza vaccine. The vaccine is still recommended because it can offer partial protection.
How serious is the interaction between Influenza virus vaccine quadrivalent and Sirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the inactivated vaccine annually despite sirolimus therapy; consider a high-dose formulation where recommended.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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