Drug interactions
Influenza virus vaccine quadrivalent + Tacrolimus
Severity: Minor
Influenza virus vaccine quadrivalent and Tacrolimus: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tacrolimus may reduce antibody response to inactivated influenza vaccine. Vaccination is still recommended because influenza is more serious in immunosuppressed patients.
What this interaction means in plain words
Influenza virus vaccine quadrivalent and Tacrolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Calcineurin inhibition suppresses T-cell-dependent vaccine responses.
What to do
Give the inactivated vaccine annually despite tacrolimus. A high-dose formulation may be considered where available.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Influenza virus vaccine quadrivalent with Tacrolimus?
MediHelp rates the interaction as minor. Influenza virus vaccine quadrivalent and Tacrolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tacrolimus may reduce antibody response to inactivated influenza vaccine. Vaccination is still recommended because influenza is more serious in immunosuppressed patients.
How serious is the interaction between Influenza virus vaccine quadrivalent and Tacrolimus?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the inactivated vaccine annually despite tacrolimus. A high-dose formulation may be considered where available.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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