Drug interactions
Influenza virus vaccine quadrivalent cell-cultured + Mycophenolate mofetil
Severity: Moderate
Influenza virus vaccine quadrivalent cell-cultured and Mycophenolate mofetil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This is an inactivated cell-culture vaccine, and mycophenolate may lessen the antibody response. Patients may have lower protection than healthy people but the vaccine is safe to give.
What this interaction means in plain words
Influenza virus vaccine quadrivalent cell-cultured and Mycophenolate mofetil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of lymphocyte proliferation via IMPDH reduces the immune response to the vaccine antigen.
What to do
Vaccinate each season and do not stop mycophenolate for this purpose. Ensure household contacts are vaccinated and consider early antiviral therapy if exposed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mycophenolate mofetil
- Adenovirus types 4 and 7 live + Mycophenolate mofetil Contraindicated
- Bcg vaccine live + Mycophenolate mofetil Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Mycophenolate mofetil Contraindicated
- Measles mumps and rubella vaccine live + Mycophenolate mofetil Contraindicated
- Measles mumps rubella and varicella vaccine live + Mycophenolate mofetil Contraindicated
- Measles vaccine + Mycophenolate mofetil Contraindicated
Frequently asked questions
Can I take Influenza virus vaccine quadrivalent cell-cultured with Mycophenolate mofetil?
MediHelp rates the interaction as moderate. Influenza virus vaccine quadrivalent cell-cultured and Mycophenolate mofetil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. This is an inactivated cell-culture vaccine, and mycophenolate may lessen the antibody response. Patients may have lower protection than healthy people but the vaccine is safe to give.
How serious is the interaction between Influenza virus vaccine quadrivalent cell-cultured and Mycophenolate mofetil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate each season and do not stop mycophenolate for this purpose. Ensure household contacts are vaccinated and consider early antiviral therapy if exposed.
What other medicines interact with Mycophenolate mofetil?
MediHelp also lists interactions of Mycophenolate mofetil with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Mycophenolate mofetil page.
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