Drug interactions
Mycophenolate mofetil + Rotavirus oral vaccine live
Severity: Contraindicated
Mycophenolate mofetil and Rotavirus oral vaccine live: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rotavirus vaccine is live attenuated, and replication may be prolonged or cause disease in patients with significant immunosuppression. Mycophenolate exposure, including in infants born to treated mothers, raises this concern.
What this interaction means in plain words
Mycophenolate mofetil and Rotavirus oral vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Impaired immune control allows replication of live attenuated rotavirus.
What to do
Avoid the live vaccine in patients on mycophenolate. For infants exposed in utero, follow specialist advice on timing.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Mycophenolate mofetil
- Adenovirus types 4 and 7 live + Mycophenolate mofetil Contraindicated
- Bcg vaccine live + Mycophenolate mofetil Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Mycophenolate mofetil Contraindicated
- Measles mumps and rubella vaccine live + Mycophenolate mofetil Contraindicated
- Measles mumps rubella and varicella vaccine live + Mycophenolate mofetil Contraindicated
- Measles vaccine + Mycophenolate mofetil Contraindicated
Frequently asked questions
Can I take Mycophenolate mofetil with Rotavirus oral vaccine live?
MediHelp rates the interaction as contraindicated. Mycophenolate mofetil and Rotavirus oral vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Rotavirus vaccine is live attenuated, and replication may be prolonged or cause disease in patients with significant immunosuppression. Mycophenolate exposure, including in infants born to treated mothers, raises this concern.
How serious is the interaction between Mycophenolate mofetil and Rotavirus oral vaccine live?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the live vaccine in patients on mycophenolate. For infants exposed in utero, follow specialist advice on timing.
What other medicines interact with Mycophenolate mofetil?
MediHelp also lists interactions of Mycophenolate mofetil with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Mycophenolate mofetil page.
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