Drug interactions
Measles mumps and rubella vaccine + Tacrolimus
Severity: Contraindicated
Measles mumps and rubella vaccine and Tacrolimus: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tacrolimus is a potent calcineurin inhibitor that suppresses T-cell immunity. The vaccine response may be reduced, and live vaccine viruses may replicate and cause vaccine-strain infection.
What this interaction means in plain words
Measles mumps and rubella vaccine and Tacrolimus are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Measles mumps and rubella vaccine belongs to Miscellaneous; Tacrolimus belongs to Miscellaneous.
Why it happens
Calcineurin inhibition suppresses T-cell activation and impairs control of live attenuated virus.
What to do
Avoid live vaccines during tacrolimus therapy. Vaccinate before transplant where possible and consult a specialist about timing afterward.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Measles mumps and rubella vaccine
- Adalimumab + Measles mumps and rubella vaccine Contraindicated
- Anakinra + Measles mumps and rubella vaccine Contraindicated
- Antithymocyte globulin equine + Measles mumps and rubella vaccine Contraindicated
- Antithymocyte globulin rabbit + Measles mumps and rubella vaccine Contraindicated
- Azathioprine + Measles mumps and rubella vaccine Contraindicated
- Basiliximab + Measles mumps and rubella vaccine Contraindicated
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Measles mumps and rubella vaccine with Tacrolimus?
MediHelp rates the interaction as contraindicated. Measles mumps and rubella vaccine and Tacrolimus are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Tacrolimus is a potent calcineurin inhibitor that suppresses T-cell immunity. The vaccine response may be reduced, and live vaccine viruses may replicate and cause vaccine-strain infection.
How serious is the interaction between Measles mumps and rubella vaccine and Tacrolimus?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live vaccines during tacrolimus therapy. Vaccinate before transplant where possible and consult a specialist about timing afterward.
What other medicines interact with Measles mumps and rubella vaccine?
MediHelp also lists interactions of Measles mumps and rubella vaccine with, for example, Adalimumab, Anakinra, Antithymocyte globulin equine. The full list is on the Measles mumps and rubella vaccine page.
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