Drug interactions
Influenza virus vaccine quadrivalent recombinant + Sirolimus
Severity: Minor
Influenza virus vaccine quadrivalent recombinant and Sirolimus: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sirolimus-related immunosuppression may reduce the antibody response to the recombinant influenza vaccine. The vaccine is non-live and safe to give, but protection may be incomplete.
What this interaction means in plain words
Influenza virus vaccine quadrivalent recombinant and Sirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Pharmacodynamic: mTOR inhibition dampens T- and B-cell responses to vaccination.
What to do
Vaccinate as recommended, ideally before transplant or at a time of lower immunosuppression; do not withhold the vaccine, and consider reinforcing protection through household immunization.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Influenza virus vaccine quadrivalent recombinant with Sirolimus?
MediHelp rates the interaction as minor. Influenza virus vaccine quadrivalent recombinant and Sirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sirolimus-related immunosuppression may reduce the antibody response to the recombinant influenza vaccine. The vaccine is non-live and safe to give, but protection may be incomplete.
How serious is the interaction between Influenza virus vaccine quadrivalent recombinant and Sirolimus?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate as recommended, ideally before transplant or at a time of lower immunosuppression; do not withhold the vaccine, and consider reinforcing protection through household immunization.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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