Drug interactions
Influenza virus vaccine trivalent adjuvanted + Oxaliplatin
Severity: Moderate
Influenza virus vaccine trivalent adjuvanted and Oxaliplatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxaliplatin-based chemotherapy suppresses bone marrow and lymphocyte function, so the antibody response to inactivated influenza vaccine may be weaker than normal. A diminished response can leave the patient less protected during influenza season.
What this interaction means in plain words
Influenza virus vaccine trivalent adjuvanted and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cytotoxic myelosuppression and lymphopenia blunt the immune response to vaccine antigens.
What to do
Vaccinate ideally at least 2 weeks before starting chemotherapy; inactivated influenza vaccine can still be given during treatment because of the infection risk. Consider revaccination after immune recovery if given close to or during chemotherapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Frequently asked questions
Can I take Influenza virus vaccine trivalent adjuvanted with Oxaliplatin?
MediHelp rates the interaction as moderate. Influenza virus vaccine trivalent adjuvanted and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxaliplatin-based chemotherapy suppresses bone marrow and lymphocyte function, so the antibody response to inactivated influenza vaccine may be weaker than normal. A diminished response can leave the patient less protected during influenza season.
How serious is the interaction between Influenza virus vaccine trivalent adjuvanted and Oxaliplatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate ideally at least 2 weeks before starting chemotherapy; inactivated influenza vaccine can still be given during treatment because of the infection risk. Consider revaccination after immune recovery if given close to or during chemotherapy.
What other medicines interact with Oxaliplatin?
MediHelp also lists interactions of Oxaliplatin with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Oxaliplatin page.
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