Drug interactions
Influenza virus vaccine trivalent adjuvanted + Sirolimus
Severity: Moderate
Influenza virus vaccine trivalent adjuvanted and Sirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sirolimus may reduce the antibody response to an inactivated influenza vaccine, so protection may be lower. The vaccine is not live and remains recommended.
What this interaction means in plain words
Influenza virus vaccine trivalent adjuvanted and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism: mTOR inhibition dampens lymphocyte proliferation and vaccine immune response.
What to do
Give the vaccine on schedule rather than withholding it, ideally before intensifying immunosuppression. Consider the importance of influenza prevention in close contacts.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Influenza virus vaccine trivalent adjuvanted with Sirolimus?
MediHelp rates the interaction as moderate. Influenza virus vaccine trivalent adjuvanted and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sirolimus may reduce the antibody response to an inactivated influenza vaccine, so protection may be lower. The vaccine is not live and remains recommended.
How serious is the interaction between Influenza virus vaccine trivalent adjuvanted and Sirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the vaccine on schedule rather than withholding it, ideally before intensifying immunosuppression. Consider the importance of influenza prevention in close contacts.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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