Drug interactions
Influenza virus vaccine trivalent adjuvanted + Tacrolimus
Severity: Moderate
Influenza virus vaccine trivalent adjuvanted and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tacrolimus can blunt the immune response to influenza vaccination, resulting in lower antibody levels and less reliable protection. The inactivated vaccine is still advised for immunosuppressed patients.
What this interaction means in plain words
Influenza virus vaccine trivalent adjuvanted and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Calcineurin inhibition suppresses T-cell help and reduces the antibody response to vaccine antigens.
What to do
Give the vaccine every season rather than withholding it, and vaccinate household contacts. Consider timing the dose when immunosuppression is lowest and monitor for influenza symptoms, treating early.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Influenza virus vaccine trivalent adjuvanted with Tacrolimus?
MediHelp rates the interaction as moderate. Influenza virus vaccine trivalent adjuvanted and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tacrolimus can blunt the immune response to influenza vaccination, resulting in lower antibody levels and less reliable protection. The inactivated vaccine is still advised for immunosuppressed patients.
How serious is the interaction between Influenza virus vaccine trivalent adjuvanted and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the vaccine every season rather than withholding it, and vaccinate household contacts. Consider timing the dose when immunosuppression is lowest and monitor for influenza symptoms, treating early.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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