Drug interactions
Influenza virus vaccine trivalent + Tacrolimus
Severity: Moderate
Influenza virus vaccine trivalent and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tacrolimus suppresses T-cell function and can blunt the antibody response to inactivated influenza vaccine. The vaccine is not live, so there is no added infection risk, and vaccination is generally still recommended in transplant recipients despite a reduced response.
What this interaction means in plain words
Influenza virus vaccine trivalent and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Calcineurin inhibition suppresses T-cell activation and impairs the immune response to vaccination.
What to do
Vaccinate annually with an inactivated vaccine, ideally before transplant or at times of lower immunosuppression. Do not withhold tacrolimus; consider a high-dose or adjuvanted formulation where available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Influenza virus vaccine trivalent with Tacrolimus?
MediHelp rates the interaction as moderate. Influenza virus vaccine trivalent and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tacrolimus suppresses T-cell function and can blunt the antibody response to inactivated influenza vaccine. The vaccine is not live, so there is no added infection risk, and vaccination is generally still recommended in transplant recipients despite a reduced response.
How serious is the interaction between Influenza virus vaccine trivalent and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate annually with an inactivated vaccine, ideally before transplant or at times of lower immunosuppression. Do not withhold tacrolimus; consider a high-dose or adjuvanted formulation where available.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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