Drug interactions
Influenza virus vaccine trivalent recombinant + Tacrolimus
Severity: Moderate
Influenza virus vaccine trivalent recombinant and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tacrolimus suppresses T-cell function and may blunt the antibody response to influenza vaccination. Protection may therefore be lower than in non-immunosuppressed individuals, though the recombinant vaccine is non-live and safe to give.
What this interaction means in plain words
Influenza virus vaccine trivalent recombinant and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Calcineurin inhibition suppresses T-cell activation and reduces vaccine immunogenicity.
What to do
Vaccinate transplant and other immunosuppressed patients annually, ideally before intensified immunosuppression when possible. Consider a high-dose or adjuvanted option where available and reinforce other preventive measures.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Influenza virus vaccine trivalent recombinant with Tacrolimus?
MediHelp rates the interaction as moderate. Influenza virus vaccine trivalent recombinant and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tacrolimus suppresses T-cell function and may blunt the antibody response to influenza vaccination. Protection may therefore be lower than in non-immunosuppressed individuals, though the recombinant vaccine is non-live and safe to give.
How serious is the interaction between Influenza virus vaccine trivalent recombinant and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate transplant and other immunosuppressed patients annually, ideally before intensified immunosuppression when possible. Consider a high-dose or adjuvanted option where available and reinforce other preventive measures.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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