Drug interactions
Inotuzumab + Oxaliplatin
Severity: Moderate
Inotuzumab and Oxaliplatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Inotuzumab ozogamicin is associated with QT prolongation, and oxaliplatin has also been linked to QT changes. Combined use may increase the risk of ventricular arrhythmias, particularly with electrolyte abnormalities.
What this interaction means in plain words
Inotuzumab and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT interval prolongation through pharmacodynamic effects.
What to do
Check ECG and electrolytes before and during treatment, and correct potassium and magnesium deficits. Avoid other QT-prolonging drugs where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Frequently asked questions
Can I take Inotuzumab with Oxaliplatin?
MediHelp rates the interaction as moderate. Inotuzumab and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Inotuzumab ozogamicin is associated with QT prolongation, and oxaliplatin has also been linked to QT changes. Combined use may increase the risk of ventricular arrhythmias, particularly with electrolyte abnormalities.
How serious is the interaction between Inotuzumab and Oxaliplatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and electrolytes before and during treatment, and correct potassium and magnesium deficits. Avoid other QT-prolonging drugs where possible.
What other medicines interact with Oxaliplatin?
MediHelp also lists interactions of Oxaliplatin with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Oxaliplatin page.
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