Drug interactions
Inotuzumab + Solifenacin
Severity: Moderate
Inotuzumab and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Inotuzumab ozogamicin can prolong the QT interval, and solifenacin may add to this effect. Together they may increase the risk of torsades de pointes in susceptible patients.
What this interaction means in plain words
Inotuzumab and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT interval prolongation.
What to do
Obtain ECG and electrolytes at baseline and during treatment. Consider an alternative to solifenacin if the QTc lengthens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Frequently asked questions
Can I take Inotuzumab with Solifenacin?
MediHelp rates the interaction as moderate. Inotuzumab and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Inotuzumab ozogamicin can prolong the QT interval, and solifenacin may add to this effect. Together they may increase the risk of torsades de pointes in susceptible patients.
How serious is the interaction between Inotuzumab and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain ECG and electrolytes at baseline and during treatment. Consider an alternative to solifenacin if the QTc lengthens.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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