Drug interactions
Inotuzumab + Tacrolimus
Severity: Major
Inotuzumab and Tacrolimus: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are associated with QT prolongation, so combined use may increase the risk of torsade de pointes. Inotuzumab also carries hepatotoxicity and veno-occlusive disease risk, which complicates tacrolimus use after transplant.
What this interaction means in plain words
Inotuzumab and Tacrolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive prolongation of cardiac repolarization (QT interval).
What to do
Obtain a baseline ECG and repeat it during treatment, and keep potassium and magnesium within normal range. Consider alternatives if the QTc becomes markedly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Inotuzumab with Tacrolimus?
MediHelp rates the interaction as major. Inotuzumab and Tacrolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents are associated with QT prolongation, so combined use may increase the risk of torsade de pointes. Inotuzumab also carries hepatotoxicity and veno-occlusive disease risk, which complicates tacrolimus use after transplant.
How serious is the interaction between Inotuzumab and Tacrolimus?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and repeat it during treatment, and keep potassium and magnesium within normal range. Consider alternatives if the QTc becomes markedly prolonged.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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