Drug interactions
Insulin aspart + Liraglutide
Severity: Moderate
Insulin aspart and Liraglutide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Liraglutide augments glucose-dependent insulin secretion and reduces appetite, so combined use with insulin raises the risk of hypoglycemia. Insulin requirements often fall after initiation.
What this interaction means in plain words
Insulin aspart and Liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin aspart belongs to Endocrine; Liraglutide belongs to Endocrine.
Why it happens
Additive glucose lowering from exogenous insulin and GLP-1 receptor agonism.
What to do
Consider reducing the insulin dose when starting liraglutide and monitor blood glucose closely. Educate the patient about hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin aspart
Other interactions of Liraglutide
Frequently asked questions
Can I take Insulin aspart with Liraglutide?
MediHelp rates the interaction as moderate. Insulin aspart and Liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Liraglutide augments glucose-dependent insulin secretion and reduces appetite, so combined use with insulin raises the risk of hypoglycemia. Insulin requirements often fall after initiation.
How serious is the interaction between Insulin aspart and Liraglutide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the insulin dose when starting liraglutide and monitor blood glucose closely. Educate the patient about hypoglycemia.
What other medicines interact with Insulin aspart?
MediHelp also lists interactions of Insulin aspart with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin aspart page.
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