Drug interactions
Insulin aspart + Losartan
Severity: Moderate
Insulin aspart and Losartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Angiotensin receptor blockers may improve insulin sensitivity, which can increase the glucose lowering effect of insulin. Hypoglycemia is possible, particularly after starting losartan.
What this interaction means in plain words
Insulin aspart and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin aspart belongs to Endocrine; Losartan belongs to Cardiovascular.
Why it happens
Angiotensin receptor blockade may enhance insulin sensitivity, adding to insulin glucose lowering effects.
What to do
Monitor blood glucose more frequently when starting or changing losartan and reduce the insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Other interactions of Insulin aspart
Frequently asked questions
Can I take Insulin aspart with Losartan?
MediHelp rates the interaction as moderate. Insulin aspart and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Angiotensin receptor blockers may improve insulin sensitivity, which can increase the glucose lowering effect of insulin. Hypoglycemia is possible, particularly after starting losartan.
How serious is the interaction between Insulin aspart and Losartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when starting or changing losartan and reduce the insulin dose if hypoglycemia occurs.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Losartan page.
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