Drug interactions
Insulin degludec + Rosiglitazone
Severity: Major
Insulin degludec and Rosiglitazone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rosiglitazone improves insulin sensitivity and enhances insulin's glucose-lowering effect, increasing hypoglycemia risk. Combination with insulin has also been associated with fluid retention, heart failure and possibly myocardial ischemia.
What this interaction means in plain words
Insulin degludec and Rosiglitazone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Insulin degludec belongs to Endocrine; Rosiglitazone belongs to Endocrine.
Why it happens
Additive glucose lowering from insulin sensitization plus exogenous insulin; fluid retention is also additive.
What to do
Monitor blood glucose and reduce the insulin dose as needed. Monitor for edema and heart failure signs, and avoid in patients with heart failure or high cardiovascular risk.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Insulin degludec and Rosiglitazone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Insulin degludec
Other interactions of Rosiglitazone
- Insulin aspart protamine / insulin aspart + Rosiglitazone Major
- Insulin aspart-insulin aspart protamine + Rosiglitazone Major
- Insulin aspart + Rosiglitazone Major
- Insulin degludec / insulin aspart + Rosiglitazone Major
- Insulin degludec-insulin aspart + Rosiglitazone Major
- Insulin degludec-liraglutide + Rosiglitazone Major
Frequently asked questions
Can I take Insulin degludec with Rosiglitazone?
MediHelp rates the interaction as major. Insulin degludec and Rosiglitazone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rosiglitazone improves insulin sensitivity and enhances insulin's glucose-lowering effect, increasing hypoglycemia risk. Combination with insulin has also been associated with fluid retention, heart failure and possibly myocardial ischemia.
How serious is the interaction between Insulin degludec and Rosiglitazone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and reduce the insulin dose as needed. Monitor for edema and heart failure signs, and avoid in patients with heart failure or high cardiovascular risk.
What other medicines interact with Insulin degludec?
MediHelp also lists interactions of Insulin degludec with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin degludec page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
