Drug interactions
Insulin aspart + Saxagliptin
Severity: Moderate
Insulin aspart and Saxagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Saxagliptin raises incretin levels, enhancing glucose-dependent insulin secretion, so combination with insulin increases hypoglycemia risk. Saxagliptin also carries a heart failure warning that matters in insulin-treated patients.
What this interaction means in plain words
Insulin aspart and Saxagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin aspart belongs to Endocrine; Saxagliptin belongs to Endocrine.
Why it happens
Additive glucose lowering from exogenous insulin and DPP-4 inhibition.
What to do
Monitor blood glucose and consider lowering the insulin dose when starting saxagliptin. Watch for heart failure symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Insulin aspart and Saxagliptin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Insulin aspart
Other interactions of Saxagliptin
- Albiglutide + Saxagliptin Moderate
- Amlodipine-benazepril + Saxagliptin Moderate
- Aripiprazole + Saxagliptin Moderate
- Asenapine + Saxagliptin Moderate
- Atazanavir + Saxagliptin Moderate
- Benazepril + Saxagliptin Moderate
Frequently asked questions
Can I take Insulin aspart with Saxagliptin?
MediHelp rates the interaction as moderate. Insulin aspart and Saxagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Saxagliptin raises incretin levels, enhancing glucose-dependent insulin secretion, so combination with insulin increases hypoglycemia risk. Saxagliptin also carries a heart failure warning that matters in insulin-treated patients.
How serious is the interaction between Insulin aspart and Saxagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and consider lowering the insulin dose when starting saxagliptin. Watch for heart failure symptoms.
What other medicines interact with Insulin aspart?
MediHelp also lists interactions of Insulin aspart with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin aspart page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
