Drug interactions
Insulin aspart-insulin aspart protamine + Liraglutide
Severity: Moderate
Insulin aspart-insulin aspart protamine and Liraglutide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Liraglutide combined with insulin increases the risk of hypoglycemia because both lower blood glucose. Insulin doses often need to be reduced when the GLP-1 agonist is introduced.
What this interaction means in plain words
Insulin aspart-insulin aspart protamine and Liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin aspart-insulin aspart protamine belongs to Endocrine; Liraglutide belongs to Endocrine.
Why it happens
Additive pharmacodynamic glucose lowering: GLP-1 receptor activation enhances glucose-dependent insulin secretion, suppresses glucagon and slows gastric emptying.
What to do
Monitor glucose closely when starting liraglutide and consider reducing the insulin dose. Adjust further according to glucose readings.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin aspart-insulin aspart protamine
- Ethanol + Insulin aspart-insulin aspart protamine Major
- Insulin aspart-insulin aspart protamine + Pentamidine Major
- Insulin aspart-insulin aspart protamine + Pioglitazone Major
- Insulin aspart-insulin aspart protamine + Rosiglitazone Major
- Acarbose + Insulin aspart-insulin aspart protamine Moderate
- Albiglutide + Insulin aspart-insulin aspart protamine Moderate
Other interactions of Liraglutide
Frequently asked questions
Can I take Insulin aspart-insulin aspart protamine with Liraglutide?
MediHelp rates the interaction as moderate. Insulin aspart-insulin aspart protamine and Liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Liraglutide combined with insulin increases the risk of hypoglycemia because both lower blood glucose. Insulin doses often need to be reduced when the GLP-1 agonist is introduced.
How serious is the interaction between Insulin aspart-insulin aspart protamine and Liraglutide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose closely when starting liraglutide and consider reducing the insulin dose. Adjust further according to glucose readings.
What other medicines interact with Insulin aspart-insulin aspart protamine?
MediHelp also lists interactions of Insulin aspart-insulin aspart protamine with, for example, Ethanol, Pentamidine, Pioglitazone. The full list is on the Insulin aspart-insulin aspart protamine page.
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