Drug interactions
Insulin aspart-insulin aspart protamine + Losartan
Severity: Minor
Insulin aspart-insulin aspart protamine and Losartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Losartan may improve insulin sensitivity and slightly enhance the effect of insulin, which can raise the risk of hypoglycemia. The effect is usually small.
What this interaction means in plain words
Insulin aspart-insulin aspart protamine and Losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Insulin aspart-insulin aspart protamine belongs to Endocrine; Losartan belongs to Cardiovascular.
Why it happens
ARBs may enhance insulin sensitivity and glucose uptake; the mechanism is not fully established.
What to do
Monitor glucose more frequently after starting losartan. Reduce the insulin dose if low readings occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Insulin aspart-insulin aspart protamine
- Ethanol + Insulin aspart-insulin aspart protamine Major
- Insulin aspart-insulin aspart protamine + Pentamidine Major
- Insulin aspart-insulin aspart protamine + Pioglitazone Major
- Insulin aspart-insulin aspart protamine + Rosiglitazone Major
- Acarbose + Insulin aspart-insulin aspart protamine Moderate
- Albiglutide + Insulin aspart-insulin aspart protamine Moderate
Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Frequently asked questions
Can I take Insulin aspart-insulin aspart protamine with Losartan?
MediHelp rates the interaction as minor. Insulin aspart-insulin aspart protamine and Losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Losartan may improve insulin sensitivity and slightly enhance the effect of insulin, which can raise the risk of hypoglycemia. The effect is usually small.
How serious is the interaction between Insulin aspart-insulin aspart protamine and Losartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose more frequently after starting losartan. Reduce the insulin dose if low readings occur.
What other medicines interact with Insulin aspart-insulin aspart protamine?
MediHelp also lists interactions of Insulin aspart-insulin aspart protamine with, for example, Ethanol, Pentamidine, Pioglitazone. The full list is on the Insulin aspart-insulin aspart protamine page.
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