Drug interactions
Insulin aspart protamine / insulin aspart + Liraglutide
Severity: Moderate
Insulin aspart protamine / insulin aspart and Liraglutide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining liraglutide with insulin adds glucose-lowering effects and raises the risk of hypoglycemia. This combination is used therapeutically but often requires an insulin dose reduction.
What this interaction means in plain words
Insulin aspart protamine / insulin aspart and Liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive glucose lowering: liraglutide enhances glucose-dependent insulin secretion and suppresses glucagon, while exogenous insulin directly lowers glucose.
What to do
Consider lowering the insulin dose when starting liraglutide and monitor blood glucose closely during titration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Liraglutide
Frequently asked questions
Can I take Insulin aspart protamine / insulin aspart with Liraglutide?
MediHelp rates the interaction as moderate. Insulin aspart protamine / insulin aspart and Liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining liraglutide with insulin adds glucose-lowering effects and raises the risk of hypoglycemia. This combination is used therapeutically but often requires an insulin dose reduction.
How serious is the interaction between Insulin aspart protamine / insulin aspart and Liraglutide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider lowering the insulin dose when starting liraglutide and monitor blood glucose closely during titration.
What other medicines interact with Liraglutide?
MediHelp also lists interactions of Liraglutide with, for example, Insulin degludec-liraglutide, Insulin glargine-lixisenatide, Alogliptin-metformin. The full list is on the Liraglutide page.
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